dna cross-links — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0164	Oxaliplatin	L-OHP	DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
	Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autop...		DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
T0974	Novobiocin Sodium	Albamycinsodium,Cathomycin,Albamycin	Potassium Channel , DNA gyrase , Topoisomerase , Antibacterial , Antibiotic , ABC , Autophagy
	Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure sim...
T1798	RITA	NSC 652287,RITA (NSC 652287)	Mdm2 , DNA Alkylator/Crosslinker , p53 , Autophagy
	RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 interaction.		Mdm2 , DNA Alkylator/Crosslinker , p53 , Autophagy
T0975	Chlorambucil	CB-1348,Chloroambucil,WR-139013	DNA Alkylator/Crosslinker , DNA Alkylation
	Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arr...		DNA Alkylator/Crosslinker , DNA Alkylation
T2410	Nedaplatin	NSC 375101D	DNA/RNA Synthesis
	Nedaplatin (NSC-375101D) is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 μM). Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand...		DNA/RNA Synthesis
T4558	Trioxsalen	Trimethylpsoralen,Trioxysalen,Trisoralen	DNA Alkylator/Crosslinker , DHFR
	Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, wh...		DNA Alkylator/Crosslinker , DHFR
T22443	Triglycidyl isocyanurate	Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,TGI	Apoptosis
	Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alk...		Apoptosis
T35271	Yoshi-864	Yoshi864,Improsulfan HCl,NSC102627,Improsulfan hydrochloride
	Yoshi-864 alkylates and cross-links DNA, thereby inhibiting DNA replication. It is an alkyl sulfonate DNA cross-linking agent with potential anti-cancer activity.
T39868	Anticancer agent 11
	Anticancer agent 11 an effective broad-spectrum anticancer agent, exerts its therapeutic potential by suppressing angiogenesis and facilitating the formation of DNA cross-links.
T69038	Teroxirone
	Teroxirone, also known as Triglycidyl Isocyanurate and Tris(2,3-epoxypropyl) Isocyanurate, is a triazene triepoxide with antineoplastic activity. Teroxine alkylates and cross-links DNA, thereby inhibiting DNA replicatio...
T34628	SG3199	SG 3199,SG-3199
	SG3199 is a PBD dimer which binds in the minor groove of DNA, and forms covalent DNA interstrand cross-links in naked linear plasmid DNA. SG3199 is potently cytotoxic against a panel of human solid tumour and haematologi...
T68592	Mafosfamide sodium
	Mafosfamide sodium is an oxazaphosphorine derivative with antineoplastic properties. It alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis.
T68434	Mafosfamide
	Mafosfamide is a synthetic oxazaphosphorine derivative with antineoplastic properties. It alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis.
T72817	Colibactin 742
	Colibactin 742, a stable derivative of colibactin, efficiently induces DNA interstrand cross-links, activates the Fanconi Anemia DNA repair pathway, and leads to G2/M arrest.
T68675	Porfiromycin
	Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radic...
T36302	PR-104
	PR-104 is a highly specific hypoxia-activated agent that cross-links DNA, enabling its application in various tumor xenograft models. Functioning as a pre-prodrug of nitrogen mustard, PR-104 undergoes efficient conversio...
T71453	TriN2755
	TriN2755 is a synthetic triazene derivative with antineoplastic activity. Upon metabolic activation via N-demethylation, TriN2755 is converted into highly reactive carbocations that can alkylate DNA and other macromolecu...
T4047L	Bisantrene HCl	CL216942,CL-216942,NSC-337766,CL 216942
	Bisantrene (CL-216942; NSC 337766) is a topoisomerase II poison and DNA intercalator. It can be used as a Rac1 inhibitor or model compound to study P-glycoprotein-mediated multi-drug resistance (MDR1). Bisantrene inserts...
T68942	Caricotamide
	Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the pro...